The Help by Kathryn Stockett is my top recommendation. It's read by multiple narrators and is, quite simply, fabulous.
Let the Great World Spin by Colum McCann - multiple narrators, in the running for my top audiobook of 2010
The Tortilla Curtain by T.C. Boyle - read by the author, a favorite of 2008
Unaccustomed Earth by Jhumpa Lahiri - outstanding collection of short stories
Water for Elephants by Sara Gruen - multiple narrators
My Sister's Keeper by Jodi Picoult - multiple narrators, the first audiobook that made me cry
Digging to America by Anne Tyler - Tyler has become an 'audio author' for me
The Falls by Joyce Carol Oates
Recently, I've turned to classics on audio.
Their Eyes Were Watching God by Zora Neale Hurston, narrated by Ruby Dee became an instant favorite
Great Expectations by Charles Dickens, narrated by Frank Muller was also outstanding
Maisie Dobbs by Jaqueline Winspeare
(narrated by Rita Barrington)
The Devil in the White City by Erik Larson (narrated by Scott Brick)
The Omnivore's Dilemma by Michael Pollan (narrated by Scott Brick)
Fast Food Nation by Eric Schlosser (narrated by Rick Adamson)
My Life in France by Julia Child
Infidel by Ayaan Hirsi Ali (read by the author)
Downtown: My Manhattan by Pete Hamill (read by the author)
Dress Your Family in Corduroy and Denim by David Sedaris (read by the author) Nobody can do David Sedaris like David Sedaris. Don't spend your time reading his books... let him read them to you. They are like nothing you've ever heard!
by Nora Ephron ( read by the author)
Again, nobody reads Nora Ephron as well as the author. This book was simply hilarious... especially if you are nearing "a certain age".